Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | OGA | O60502 | 3/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.33 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640240 | 1.00 | HRH3 (0.36) | HRH3POLBNR1H2NR1H3ACACB | |
| SCHEMBL24640193 | 0.88 | POLB (0.38) | HRH3POLBNR1H2NR1H3ACACB | |
| SCHEMBL24640184 | 0.88 | POLB (0.38) | HRH3POLBNR1H2NR1H3ACACB | |
| SCHEMBL24640243 | 0.88 | POLB (0.38) | HRH3POLBNR1H2NR1H3ACACB | |
| SCHEMBL26958206 | 0.86 | SMN1; SMN2 (0.40) | HRH3POLBNR1H2NR1H3HTR2B | |
| SCHEMBL24640236 | 0.83 | HRH3 (0.32) | HRH3MDM2 | |
| SCHEMBL24640235 | 0.81 | HRH3 (0.33) | HRH3NR1H2NR1H3 | |
| SCHEMBL24640155 | 0.80 | CHRM2 (0.37) | HRH3POLBNR1H2NR1H3ACACB | |
| SCHEMBL26958078 | 0.80 | CHRM2 (0.37) | HRH3POLBNR1H2NR1H3ACACB | |
| SCHEMBL24640697 | 0.80 | HRH3 (0.31) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |