Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | TIPARP | Q7Z3E1 | 10/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26958161 | 0.85 | HTR2A (0.40) | SOS1TIPARPPARP2HTR2B | |
| SCHEMBL24640930 | 0.84 | SOS1 (0.35) | SOS1TIPARP | |
| SCHEMBL26958276 | 0.81 | HRH3 (0.33) | SOS1HRH3HTR2B | |
| SCHEMBL24639389 | 0.79 | TIPARP (0.49) | SOS1TIPARPPARP2CHRM2HTR1A | |
| SCHEMBL24639352 | 0.79 | TIPARP (0.49) | SOS1TIPARPPARP2CHRM2HTR1A | |
| SCHEMBL24639355 | 0.79 | TIPARP (0.49) | SOS1TIPARPPARP2CHRM2HTR1A | |
| SCHEMBL24639880 | 0.77 | HRH3 (0.31) | HRH3 | |
| SCHEMBL31245317 | 0.76 | HTR2A (0.44) | HTR2B | |
| SCHEMBL29842014 | 0.76 | HTR2A (0.44) | HTR2B | |
| SCHEMBL29842130 | 0.76 | HSD11B1 (0.38) | CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |