Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640161 | 1.00 | HRH3 (0.38) | HRH3ADRA2AADRA2BADRA2CCYP1A2 | |
| SCHEMBL24763844 | 0.79 | HTR2B (0.40) | HRH3ADRA2AADRA2BADRA2CCYP1A2 | |
| SCHEMBL24640808 | 0.79 | LTA4H (0.37) | HRH3ADRA2AADRA2BADRA2CCYP1A2 | |
| SCHEMBL24640717 | 0.79 | LTA4H (0.37) | HRH3ADRA2AADRA2BADRA2CCYP1A2 | |
| SCHEMBL24640038 | 0.77 | SOS1 (0.41) | HRH3HTR2AHTR2CHTR2BPDE10A | |
| SCHEMBL24640702 | 0.77 | SOS1 (0.41) | HRH3HTR2AHTR2CHTR2BPDE10A | |
| SCHEMBL24640703 | 0.77 | SOS1 (0.41) | HRH3HTR2AHTR2CHTR2BPDE10A | |
| SCHEMBL24639936 | 0.71 | HTR2A (0.42) | HRH3ADRA2AADRA2BADRA2CCYP1A2 | |
| SCHEMBL24640622 | 0.71 | HRH3 (0.38) | HRH3ADRA2AADRA2BADRA2CCYP1A2 | |
| SCHEMBL24640708 | 0.71 | HRH3 (0.38) | HRH3ADRA2AADRA2BADRA2CCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |