Ethyne

Ethyne

SCHEMBL2464124

C#C.C1=Cc2cc3ccc(cc4nc(cc5ccc(cc1n2)[nH]5)C=C4)[nH]3

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.40
▸ STAT1 P42224 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethyne SCHEMBL7906227 1.00 STAT3 (0.40) STAT3STAT1
Ethyne SCHEMBL4786315 0.98 STAT3 (0.39) STAT3STAT1
Ethyne SCHEMBL27998993 0.98 STAT3 (0.39) STAT3STAT1
SCHEMBL6517023 0.95 STAT3 (0.42) STAT3STAT1
SCHEMBL29430977 0.95 STAT3 (0.42) STAT3STAT1
SCHEMBL9430673 0.95 STAT3 (0.42) STAT3STAT1
SCHEMBL15809 0.95 STAT3 (0.42) STAT3STAT1
SCHEMBL6744970 0.95 STAT3 (0.42) STAT3STAT1
SCHEMBL30821407 0.95 STAT3 (0.42) STAT3STAT1
Cyanide SCHEMBL5505438 0.93 STAT3 (0.39) STAT3STAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107805254-A A kind of porphyrin small molecule perovskite cathode cushioning layer material and preparation method and application 华南理工大学 2018-03-16 — — CN claimed
EP-1546284-B1 REACTIVE DENDRIMERS UNIV OXFORD INNOVATION LTD (GB) 2018-04-04 — — EP disclosed
CN-107805254-A A kind of porphyrin small molecule perovskite cathode cushioning layer material and preparation method and application 华南理工大学 2018-03-16 — — CN disclosed
US-8025988-B2 Reactive organometallic dendrimers ISIS INNOVATION LIMITED (GB) 2011-09-27 — — US disclosed
US-20100228022-A1 Reactive Organometallic Dendrimers CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2010-09-09 — — US disclosed
US-7740954-B2 Reactive dendrimers ISIS INNOVATION LIMITED (GB) 2010-06-22 — — US disclosed
US-20050164029-A1 Reactive dendrimers CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2005-07-28 — — US disclosed
EP-1546284-A1 REACTIVE DENDRIMERS ISIS INNOVATION LIMITED (GB) 2005-06-29 — — EP disclosed
WO-2004020547-A1 REACTIVE DENDRIMERS ISIS INNOVATION LIMITED (GB) 2004-03-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100228022-A1 Reactive Organometallic Dendrimers ITGAM, CD40LG, DBN1 STAT3 1576/4885STAT1 952/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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