Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.60 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2136444 | 0.85 | HDAC2 (0.53) | HDAC2TNFRSF1ALMNAHDAC1MAPT | |
| SCHEMBL4794017 | 0.84 | HDAC2 (0.44) | HDAC2TNFRSF1AHDAC1HDAC3KDM4E | |
| SCHEMBL2464868 | 0.82 | HDAC2 (0.49) | HDAC2TNFRSF1AHDAC1MAPTHDAC3 | |
| SCHEMBL2468234 | 0.82 | HDAC2 (0.47) | HDAC2TNFRSF1ALMNAHDAC1RECQL | |
| SCHEMBL4579847 | 0.80 | RAB9A (0.52) | HDAC2LMNAHDAC1MAPTHDAC3 | |
| SCHEMBL4579383 | 0.77 | HDAC2 (0.44) | HDAC2LMNAHDAC1MAPTHDAC3 | |
| SCHEMBL29898509 | 0.73 | HDAC2 (0.48) | HDAC2TNFRSF1AHDAC1MAPTRXFP1 | |
| SCHEMBL29898510 | 0.73 | HDAC2 (0.48) | HDAC2TNFRSF1AHDAC1MAPTRXFP1 | |
| SCHEMBL11827219 | 0.73 | HDAC2 (0.72) | HDAC2TNFRSF1AHDAC1MAPTHDAC3 | |
| SCHEMBL5471588 | 0.73 | HDAC2 (0.72) | HDAC2TNFRSF1AHDAC1MAPTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007720-B1 | BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2013-12-25 | — | — | EP | disclosed |
| US-8598168-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2013-12-03 | — | — | US | disclosed |
| EP-2367599-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | Massachusetts Institute of Technology (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010065117-A1 | INHIBITION OF HDAC2 TO PROMOTE MEMORY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC2 5/4885TNFRSF1A 3142/4885LMNA 1922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.