Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1066552 | 0.86 | ABL1 (0.52) | HDAC2HPGDSHDAC1HDAC3L3MBTL1 | |
| SCHEMBL2464650 | 0.84 | HDAC2 (0.60) | HDAC2HDAC1HDAC3TNFRSF1AKDM4E | |
| SCHEMBL2685210 | 0.84 | GPR119 (0.43) | HDAC2HPGDSHDAC1HDAC3L3MBTL1 | |
| SCHEMBL4669170 | 0.84 | HDAC1 (0.48) | HPGDSHDAC1DRD2DRD4HTR2A | |
| SCHEMBL4579392 | 0.83 | HPGDS (0.46) | HPGDSHDAC1DRD2DRD4HTR2A | |
| SCHEMBL4580709 | 0.79 | TDP1 (0.51) | HDAC2HPGDSHDAC1HDAC3L3MBTL1 | |
| SCHEMBL4579334 | 0.77 | HPGDS (0.40) | HDAC2HPGDSHDAC1HDAC3L3MBTL1 | |
| SCHEMBL1068512 | 0.76 | ABL1 (0.54) | HDAC2HDAC1HDAC3L3MBTL1KDM4E | |
| SCHEMBL29898509 | 0.75 | HDAC2 (0.48) | HDAC2HDAC1HDAC3TNFRSF1AKDM4E | |
| SCHEMBL29898510 | 0.75 | HDAC2 (0.48) | HDAC2HDAC1HDAC3TNFRSF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991226-A2 | INHIBITORS OF HISTONE DEACETYLASE | Merck & Co., Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007100657-A2 | INHIBITORS OF HISTONE DEACETYLASE | MERCK & CO., INC. (US) | 2007-09-07 | — | — | WO | disclosed |