Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19956885 | 0.84 | ALDH1A1 (0.63) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| SCHEMBL294341 | 0.83 | ALDH1A1 (0.73) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| SCHEMBL1177836 | 0.83 | ALDH1A1 (0.73) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| SCHEMBL1834864 | 0.81 | ALDH1A1 (0.70) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| SCHEMBL8069055 | 0.81 | ALDH1A1 (0.70) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| SCHEMBL217571 | 0.81 | ALDH1A1 (0.77) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| SCHEMBL10432827 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| SCHEMBL361779 | 0.81 | ALDH1A1 (1.00) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A | |
| SCHEMBL23760102 | 0.80 | TDP1 (0.63) | ALDH1A1MAPK1L3MBTL1TDP1LMNA | |
| SCHEMBL30996079 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPK1L3MBTL1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239139-A1 | CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE | Shenzhen Salubris Pharmaceuticals Co., Ltd (CN) | 2017-11-01 | — | — | EP | disclosed |
| CN-105566179-B | A kind of method for preparing chiral alpha fluorine beta amino acids derivative | 上海工程技术大学 | 2017-09-05 | — | — | CN | disclosed |
| EP-2612857-B1 | CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE | SHENZHEN SALUBRIS PHARM CO LTD (CN) | 2017-07-26 | — | — | EP | disclosed |
| US-20160122358-A1 | NOVEL SUBSTITUTED PYRAZOLO-PIPERAZINES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-05-05 | — | — | US | disclosed |
| US-9273058-B2 | Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-03-01 | — | — | US | disclosed |
| WO-2015073763-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |
| US-20150133428-A1 | NOVEL SUBSTITUTED PYRAZOLO-PIPERAZINES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-05-14 | — | — | US | disclosed |
| EP-2612857-A1 | CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE | Institute of Mataria Medica, Chinese Academy of Medical Sciences (CN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012001486-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF PRASUGREL HYDROCHLORIDE AND ITS INTERMEDIATES | MAYUKA LABS PVT. LTD. (IN) | 2012-01-05 | — | — | WO | disclosed |
| CN-101312970-A | 6-heteroaryl pyridoindolone derivatives, their preparation and their therapeutic use | SANOFI AVENTIS (FR) | 2008-11-26 | — | — | CN | disclosed |
| US-4518528-A | α Amino fluoro ketones | MP BIOMEDICALS, LLC | 1985-05-21 | — | — | US | disclosed |
| EP-0130679-A2 | Alpha amino fluoro ketones | ENZYME SYSTEMS PRODUCTS INC. (US) | 1985-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122358-A1 | NOVEL SUBSTITUTED PYRAZOLO-PIPERAZINES AS CASEIN KINASE 1 D/E INHIBITORS | CSNK1E, CSNK1A1, CSNK1G1 | ALDH1A1 2162/4885MAPK1 79/4885L3MBTL1 3554/4885 |
| US-20150133428-A1 | NOVEL SUBSTITUTED PYRAZOLO-PIPERAZINES AS CASEIN KINASE 1 D/E INHIBITORS | CSNK1E, CSNK1A1, CSNK1G1 | ALDH1A1 2162/4885MAPK1 79/4885L3MBTL1 3554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.