⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10442618 | 0.73 | MEN1 (0.35) | — | |
| SCHEMBL7057595 | 0.72 | — | — | |
| SCHEMBL1191487 | 0.71 | MEN1 (0.40) | — | |
| SCHEMBL1205563 | 0.69 | — | — | |
| SCHEMBL642226 | 0.69 | — | — | |
| SCHEMBL1512232 | 0.69 | — | — | |
| SCHEMBL536875 | 0.69 | — | — | |
| SCHEMBL16654263 | 0.67 | — | — | |
| SCHEMBL558876 | 0.67 | ESR1 (0.34) | — | |
| SCHEMBL15923447 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11964960-B2 | Pyridinone- and pyridazinone-based compounds and uses thereof | CORNELL UNIVERSITY (US) | 2024-04-23 | — | — | US | disclosed |
| US-20200407339-A1 | PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND USES THEREOF | TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE | 2020-12-31 | — | — | US | disclosed |
| CN-110198943-A | 1,2- dihydro -3H- pyrazoles [3,4-d] pyrimidine -3- ketone derivatives as Wee1 inhibitor | 石家庄智康弘仁新药开发有限公司 | 2019-09-03 | — | — | CN | disclosed |
| CN-108602796-A | azole-substituted pyridine compound | 大正制药株式会社 | 2018-09-28 | — | — | CN | disclosed |
| CN-103874700-B | Pyrazolo [3,4-c ] pyridine compounds and methods of use | 霍夫曼-拉罗奇有限公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-106879256-A | 2 aminobenzimidazole derivatives and its application as 5 LOXs and/or prostaglandin-e synthetase inhibitors | 韩国巴斯德研究所 | 2017-06-20 | — | — | CN | disclosed |
| CN-105189494-B | Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors | 普罗克西梅根有限公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-104016971-B | Antiviral compound | PHARMASSET INC. (US) | 2016-05-25 | — | — | CN | disclosed |
| CN-101679408-B | Bicyclic heterocyclic compounds as FGFR inhibitors | ASTEX THERAPEUTICS LTD. (GB) | 2016-04-27 | — | — | CN | disclosed |
| CN-102993084-B | Alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA | 2015-05-20 | — | — | CN | disclosed |
| CN-101835755-B | Novel kinase inhibitors | HOFFMANN LA ROCHE | 2013-12-11 | — | — | CN | disclosed |
| CN-103228651-A | Compounds useful as inhibitors of atr kinase | VERTEX PHARMA | 2013-07-31 | — | — | CN | disclosed |
| EP-2542077-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | Merck Sharp & Dohme Corp. (US) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109261-A1 | INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS | MERCK SHARP & DOHME CORP. (US) | 2011-09-09 | — | — | WO | disclosed |
| CN-101679361-A | Certain substituted amides, methods of making and methods of use thereof | CGI PHARMACEUTICALS INC | 2010-03-24 | — | — | CN | disclosed |
| CN-101605778-A | The acid amides of some replacement, its preparation method and using method | CGI PHARMACEUTICALS INC (US) | 2009-12-16 | — | — | CN | disclosed |
| CN-101223141-A | Certain substituted amides, method of making, and method of use thereof | CGI PHARMACEUTICALS INC (US) | 2008-07-16 | — | — | CN | disclosed |
| EP-1909910-A1 | BENZIMIDAZOLE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019416-A1 | BENZIMIDAZOLE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |
| CN-1034715-A | N-cyanogen methyl-2-pyridinone insecticides | DOW CHEMICAL CO (US) | 1989-08-16 | — | — | CN | disclosed |