Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Dl-Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.85 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.85 |
| ▸ | ALPI | P09923 | 1/20 | 0.85 |
| ▸ | PKM | P14618 | 1/20 | 0.85 |
| ▸ | XIAP | P98170 | 1/20 | 0.85 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.61 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.61 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.61 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL27873303 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL246543 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL11240666 | 0.98 | SLC7A5 (0.81) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL8610376 | 0.93 | SLC7A5 (0.79) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL8610372 | 0.93 | SLC7A5 (0.79) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL23159186 | 0.92 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL8118 | 0.92 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL16398196 | 0.92 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL385804 | 0.92 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL8119 | 0.92 | SLC7A5 (1.00) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101684076-B | Process for preparing amides | CHINA PETROCHEMICAL DEV CORP | 2013-04-17 | — | — | CN | claimed |
| CN-102146051-B | Method for separating amide from amino acid ionic liquid | CHINA PETROCHEMICAL DEV CORP | 2013-03-27 | — | — | CN | claimed |
| CN-102039179-B | Catalytic composition for preparing amide and method for preparing amide | CHINA PETROCHEMICAL DEV CORP | 2013-03-06 | — | — | CN | claimed |
| CN-102146051-A | Method for separating amide from amino acid ionic liquid | CHINA PETROCHEMICAL DEV CORP | 2011-08-10 | — | — | CN | claimed |
| CN-102039179-A | Catalytic composition for preparing amide and method for preparing amide | CHINA PETROCHEMICAL DEV CORP | 2011-05-04 | — | — | CN | claimed |
| CN-101684076-A | Process for preparing amides | CHINA PETROCHEMICAL DEV CORP | 2010-03-31 | — | — | CN | claimed |
| CN-113651959-B | Nanometer medicine carrying system based on amino acid-hydroxy acid copolymer and preparation method and application thereof | 中山大学 | 2024-05-07 | — | — | CN | disclosed |
| CN-114438566-B | Aluminum product anodic oxidation liquid and use method thereof | 四川大学 | 2024-02-23 | — | — | CN | disclosed |
| CN-114438566-A | Aluminum material anodic oxidation liquid and use method thereof | 四川大学 | 2022-05-06 | — | — | CN | disclosed |
| CN-112603908-B | Nano drug-loading system based on amino acid polymer and preparation method and application thereof | 中山大学 | 2022-02-08 | — | — | CN | disclosed |
| CN-113651959-A | Nano drug loading system based on amino acid-hydroxy acid copolymer and preparation method and application thereof | 中山大学 | 2021-11-16 | — | — | CN | disclosed |
| CN-112603908-A | Nano drug-loading system based on amino acid polymer and preparation method and application thereof | 中山大学 | 2021-04-06 | — | — | CN | disclosed |
| CN-108135944-A | Probiotics and prebiotic compositions and its method and purposes for adjusting microorganism group | 伊夫罗生物科学公司 | 2018-06-08 | — | — | CN | disclosed |
| EP-0376230-B1 | Preparation and isolation of mineral acid salt of an amino methyl ester | MITSUI TOATSU CHEMICALS (JP) | 1994-11-23 | — | — | EP | disclosed |
| US-5113009-A | PREPARATION AND ISOLATION OF MINERAL ACID SALT OF AN AMINO ACID METHYL ESTER | MITSUI TOATSU CHEMICALS, INCORPORATED | 1992-05-12 | — | — | US | disclosed |
| EP-0376230-A2 | Preparation and isolation of mineral acid salt of an amino methyl ester | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-07-04 | — | — | EP | disclosed |
| EP-0057092-B1 | PROCESS FOR RACEMIZING AN OPTICALLY ACTIVE ALPHA-AMINO ACID OR A SALT THEREOF | Tanabe Seiyaku Co., Ltd. (JP) | 1985-05-02 | — | — | EP | disclosed |
| US-4427762-A | DEVELOPMENT WITH ALKALINE DEVELOPER MIXTURE | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1984-01-24 | — | — | US | disclosed |
| US-4401820-A | IN THE PRESENCE OF AN ACYCLIC ACID AND AN ALDEHYDE; STABILITY | TANABE SEIYAKU CO., LTD. (JP) | 1983-08-30 | — | — | US | disclosed |
| EP-0057092-A1 | Process for racemizing an optically active alpha-amino acid or a salt thereof | Tanabe Seiyaku Co., Ltd. (JP) | 1982-08-04 | — | — | EP | disclosed |