SCHEMBL24655593

SCHEMBL24655593

Cc1ccc(-c2cc3cccnc3[nH]2)cc1

nearest known ligand 0.71

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 19/20 0.71
CCNB2 O95067 2/20 0.70
CDK1 P06493 2/20 0.70
CCNB1 P14635 2/20 0.70
CCNB3 Q8WWL7 2/20 0.70
GSK3A P49840 1/20 0.61
GSK3B P49841 1/20 0.61
CDK5 Q00535 1/20 0.61
CDK5R1 Q15078 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5604499 0.87 RIPK1 (0.67) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL1778505 0.84 RIPK1 (0.74) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL18741322 0.83 RIPK1 (1.00) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL7892114 0.83 RIPK1 (0.71) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL31265224 0.83 RIPK1 (0.71) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL5907874 0.83 RIPK1 (0.71) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL1780494 0.83 RIPK1 (0.71) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL31065045 0.83 RIPK1 (1.00) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL26053438 0.83 RIPK1 (0.71) RIPK1CCNB2CDK1CCNB1CCNB3
SCHEMBL31064954 0.83 RIPK1 (1.00) RIPK1CCNB2CDK1CCNB1CCNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230241031-A1 Composition, Comprising Rip Kinase Inhibitor, For Preventing Hair Loss Or Promoting Hair Regrowth EPI BIOTECH CO., LTD. (KR) 2023-08-03 US disclosed
EP-4046635-A1 COMPOSITION, COMPRISING RIP KINASE INHIBITOR, FOR PREVENTING HAIR LOSS OR PROMOTING HAIR REGROWTH Epi Biotech Co., Ltd. (KR) 2022-08-24 EP disclosed
CN-109320512-A A kind of synthetic method of azaindole substituted aryl Ethyl formate compound 江苏理工学院 2019-02-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230241031-A1 Composition, Comprising Rip Kinase Inhibitor, For Preventing Hair Loss Or Promoting Hair Regrowth RIPK1, RIPK2, RIPK4 RIPK1 1/4885CCNB2 2498/4885CDK1 720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.