Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.54 |
| ▸ | F10 | P00742 | 4/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2515230 | 0.83 | IGF1R (0.51) | IGF1R | |
| SCHEMBL6014692 | 0.82 | IGF1R (0.45) | IGF1RF10 | |
| SCHEMBL5400222 | 0.79 | IGF1R (0.43) | IGF1R | |
| SCHEMBL5078897 | 0.72 | TNK2 (0.40) | IGF1R | |
| SCHEMBL13504863 | 0.72 | TNK2 (0.53) | — | |
| SCHEMBL2460643 | 0.71 | IGF1R (0.75) | IGF1R | |
| SCHEMBL2457076 | 0.70 | IGF1R (1.00) | IGF1R | |
| SCHEMBL5083550 | 0.66 | IGF1R (0.40) | IGF1R | |
| SCHEMBL5082928 | 0.66 | IGF1R (0.40) | IGF1R | |
| SCHEMBL5086159 | 0.66 | TNK2 (0.35) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-B1 | IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS | OSI PHARM INC (US) | 2011-09-21 | — | — | EP | disclosed |