Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5400222 | 0.89 | IGF1R (0.43) | IGF1RTNK2 | |
| SCHEMBL2465616 | 0.82 | IGF1R (0.54) | IGF1RF10 | |
| SCHEMBL2515230 | 0.77 | IGF1R (0.51) | IGF1R | |
| SCHEMBL2457658 | 0.74 | IGF1R (0.80) | IGF1RTNK2 | |
| SCHEMBL2462739 | 0.71 | IGF1R (0.72) | IGF1RTNK2 | |
| SCHEMBL5083250 | 0.71 | TNK2 (0.45) | IGF1RTNK2 | |
| Formic Acid SCHEMBL4140220 | 0.71 | IGF1R (0.74) | IGF1RTNK2 | |
| SCHEMBL1129460 | 0.69 | TNK2 (0.57) | IGF1RTNK2 | |
| SCHEMBL2460643 | 0.69 | IGF1R (0.75) | IGF1R | |
| SCHEMBL5078897 | 0.68 | TNK2 (0.40) | IGF1RTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-A2 | IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037836-A2 | IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |