Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL27676626 | 0.86 | SMN1; SMN2 (0.79) | SMN1; SMN2KMOMAPT | |
| SCHEMBL10777427 | 0.82 | KMT2A (0.48) | SMN1; SMN2FFAR1ACHEKMT2AALDH1A1 | |
| SCHEMBL10782076 | 0.82 | ALDH1A1 (0.58) | SMN1; SMN2KMOKMT2AALDH1A1LMNA | |
| Malic Acid SCHEMBL27794963 | 0.81 | SMN1; SMN2 (0.88) | SMN1; SMN2KMO | |
| Malic Acid SCHEMBL9782806 | 0.81 | SMN1; SMN2 (0.88) | SMN1; SMN2LMNAMAPT | |
| Malic Acid SCHEMBL856 | 0.81 | — | — | |
| Malic Acid SCHEMBL98496 | 0.81 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2KMOLMNA | |
| Malic Acid SCHEMBL31673494 | 0.81 | — | — | |
| Malic Acid SCHEMBL31673489 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8025840-B2 | Compositions and methods for inhibiting corrosion in aqueous media | GENERAL ELECTRIC COMPANY (US) | 2011-09-27 | — | — | US | claimed |