Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.88 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.50 |
| ▸ | TET3 | O43151 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL30036864 | 0.94 | — | — | |
| Malic Acid SCHEMBL30036315 | 0.94 | — | — | |
| Malic Acid SCHEMBL30036890 | 0.94 | — | — | |
| Malic Acid SCHEMBL89131 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3SLC22A6TET1 | |
| Malic Acid SCHEMBL256122 | 0.94 | — | — | |
| Malic Acid SCHEMBL31673494 | 0.94 | — | — | |
| Malic Acid SCHEMBL98496 | 0.94 | — | — | |
| Malic Acid SCHEMBL31673489 | 0.94 | — | — | |
| Malic Acid SCHEMBL856 | 0.94 | — | — | |
| Malic Acid SCHEMBL14125844 | 0.94 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3SLC22A6TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107159470-B | A kind of phosphorite flotation collector | 嘉兴市南湖区翊轩塑料五金厂（普通合伙） | 2019-01-18 | — | — | CN | claimed |
| CN-107159470-A | A kind of phosphorite flotation collector | 常州市万昌化工有限公司 | 2017-09-15 | — | — | CN | claimed |
| CN-107029894-A | A kind of preparation method of low temperature resistant mid-low grade collophanite ore flotation collector | 常州大学 | 2017-08-11 | — | — | CN | claimed |
| CN-113975224-B | Ionic liquid-reversed micelle drug-loaded delivery system for epidermis desensitization treatment, and preparation method and application thereof | 中国药科大学 | 2023-10-24 | — | — | CN | disclosed |
| CN-113975224-A | Ionic liquid-reversed micelle drug-loading delivery system for epidermal desensitization treatment and preparation method and application thereof | 中国药科大学 | 2022-01-28 | — | — | CN | disclosed |
| CN-107159470-B | A kind of phosphorite flotation collector | 嘉兴市南湖区翊轩塑料五金厂（普通合伙） | 2019-01-18 | — | — | CN | disclosed |
| CN-108137344-A | The transistion metal compound based on cyanide that surface is modified | 爱尔威欧能源有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107159470-A | A kind of phosphorite flotation collector | 常州市万昌化工有限公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-107029894-A | A kind of preparation method of low temperature resistant mid-low grade collophanite ore flotation collector | 常州大学 | 2017-08-11 | — | — | CN | disclosed |
| US-4996307-A | Dissolving water insoluble chitosan in aqueous acid solution, diluting, adding acylating agent | LION CORPORATION (JP) | 1991-02-26 | — | — | US | disclosed |