Vanoxerine

Vanoxerine

SCHEMBL246574

Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 6/20 1.00
SLC6A3 Q01959 6/20 1.00
SIGMAR1 Q99720 5/20 1.00
SLC6A2 P23975 4/20 1.00
SMN1; SMN2 Q16637 4/20 1.00
MAPK1 P28482 3/20 1.00
MEN1 O00255 3/20 1.00
ALDH1A1 P00352 3/20 1.00
LMNA P02545 3/20 1.00
KMT2A Q03164 3/20 1.00
CYP2D6 P10635 3/20 1.00
TDP1 Q9NUW8 2/20 1.00
TP53 P04637 2/20 1.00
CYP1A2 P05177 2/20 1.00
MAPT P10636 2/20 1.00
CYP2C9 P11712 2/20 1.00
TSHR P16473 2/20 1.00
NFKB1 P19838 2/20 1.00
CYP2C19 P33261 2/20 1.00
THPO P40225 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10000765 0.99 SLC6A4 (0.97) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
Vanoxerine SCHEMBL725103 0.99 SLC6A4 (1.00) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
Vanoxerine SCHEMBL15541249 0.99 SLC6A4 (1.00) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
Vanoxerine SCHEMBL3014060 0.97 SLC6A4 (0.95) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
SCHEMBL6254945 0.95 SLC6A4 (0.90) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
SCHEMBL24221220 0.94 SLC6A4 (0.88) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
Hydrochloric Acid SCHEMBL11374533 0.94 SLC6A4 (0.90) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
Hydrochloric Acid SCHEMBL11380714 0.92 SLC6A4 (0.88) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
Vanoxerine SCHEMBL11373792 0.91 SLC6A4 (0.83) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2
Vanoxerine SCHEMBL11373788 0.91 SLC6A4 (0.83) SLC6A4SLC6A3SIGMAR1SLC6A2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1434 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4618976-A1 COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL CONDITIONS Dri Biosciences Corporation (US) 2025-09-24 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-12310934-B2 Methods of treatment of spontaneous preterm birth THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-05-27 US claimed
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. 2025-01-30 US claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 WO claimed
US-20240398978-A1 Compositions and Methods for Treating Dopamine Disorders METAQOR LLC (US) 2024-12-05 US claimed
EP-3386493-B1 DBH INHIBITORS FOR TREATING OR PREVENTING MEMORY LOSS UNIV BRANDEIS (US) 2024-11-20 EP claimed
WO-2024107961-A1 COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL CONDITIONS DRI BIOSCIENCES CORPORATION (US) 2024-05-23 WO claimed
US-20240148745-A1 COMPOUNDS FOR USE IN PROGRESSIVE MULTIPLE SCLEROSIS FONDAZIONE CENTRO SAN RAFFAELE (IT) 2024-05-09 US claimed
WO-2002030422-A1 USE OF DEFINED SUBSTANCES THAT BIND TO THE SIGMA RECEPTOR FOR COMBATING SARCOMA AND CARCINOMA MERCK PATENT GMBH (DE) 2002-04-18 WO claimed
US-20020019421-A1 Compositions and therapy for substance addiction BIBERMAN RONI (IL) 2002-02-14 US claimed
JP-2001506978-A 2001-05-29 JP claimed
EP-0937053-A1 SUSTAINED-RELEASE DERIVATIVES OF HYDROXYLATED ANALOGS OF SUBSTITUTED 1- 2 BIS(ARYL)METHOXY]ETHYL]-PIPERAZINES AND -HOMOPIPERAZINES AND THEIR USE AS NONCOMPETITIVE ANTAGONISTS OF DOPAMINE REUPTAKE THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services (US) 1999-08-25 EP claimed
WO-1998018769-A1 SUSTAINED-RELEASE DERIVATIVES OF HYDROXYLATED ANALOGS OF SUBSTITUTED 1-[2[BIS(ARYL)METHOXY]ETHYL]-PIPERAZINES AND -HOMOPIPERAZINES AND THEIR USE AS NONCOMPETITIVE ANTAGONISTS OF DOPAMINE REUPTAKE THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-05-07 WO claimed
US-5366975-A Pesticides THE GENERAL HOSPITAL CORPORATION (US) 1994-11-22 US claimed
EP-0485512-A4 SLOWLY DISSOCIATING (TIGHT BINDING) DOPAMINE, SEROTONIN OR NOREPINEPHRINE REUPTAKE INHIBITORS AS COCAINE, AMPHETAMINE AND PHENCYCLIDINE ANTAGONISTS US HEALTH (US) 1992-08-26 EP claimed
EP-0485512-A1 SLOWLY DISSOCIATING (TIGHT BINDING) DOPAMINE, SEROTONIN OR NOREPINEPHRINE REUPTAKE INHIBITORS AS COCAINE ANTAGONISTS. THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) 1992-05-20 EP claimed
WO-1991001732-A1 SLOWLY DISSOCIATING (TIGHT BINDING) DOPAMINE, SEROTONIN OR NOREPINEPHRINE REUPTAKE INHIBITORS AS COCAINE, AMPHETAMINE AND PHENCYCLIDINE ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) 1991-02-21 WO claimed
US-4202896-A DOPAMINERGIC ACTIVITY GIST-BROCADES N.V. (NL) 1980-05-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE TACR1, ACHE, TACR2 SLC6A4 1763/4885SLC6A3 1329/4885SIGMAR1 554/4885
US-20240398978-A1 Compositions and Methods for Treating Dopamine Disorders SLC6A3, SNCA, CLTA SLC6A4 42/4885SLC6A3 1/4885SIGMAR1 182/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.