Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 4/20 | 0.55 |
| ▸ | FAAH | O00519 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LIPE | Q05469 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4198448 | 0.87 | MAPK1 (0.56) | MAPK1RAB9ATHRBMGLLFAAH | |
| SCHEMBL30334879 | 0.82 | MAPK1 (0.67) | MAPK1RAB9ATHRBFAAHALDH1A1 | |
| SCHEMBL20381754 | 0.82 | MAPK1 (0.71) | MAPK1RAB9ATHRBALDH1A1POLB | |
| SCHEMBL6531818 | 0.82 | MAPK1 (0.75) | MAPK1RAB9ATHRBFAAHALDH1A1 | |
| SCHEMBL1011398 | 0.82 | THRB (0.72) | MAPK1RAB9ATHRBFAAHALDH1A1 | |
| SCHEMBL10500983 | 0.82 | MAPK1 (0.67) | MAPK1RAB9ATHRBFAAHALDH1A1 | |
| SCHEMBL2424855 | 0.82 | MAPK1 (0.62) | MAPK1RAB9ATHRBMGLLALDH1A1 | |
| SCHEMBL1009491 | 0.82 | MAPK1 (0.66) | MAPK1THRBMGLLFAAHALDH1A1 | |
| SCHEMBL906222 | 0.81 | LMNA (0.63) | MAPK1RAB9ATHRBLMNAKMT2A | |
| SCHEMBL30690168 | 0.81 | LMNA (0.63) | MAPK1RAB9ATHRBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279470-B2 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK A/S (DK) | 2007-10-09 | — | — | US | disclosed |
| US-7067517-B2 | Use of compounds for decreasing activity of hormone-sensitive lipase | NERO NORDISK A/S (DK) | 2006-06-27 | — | — | US | disclosed |
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| EP-1458375-A2 | COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
| WO-2003051842-A2 | COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
| US-4401460-A | Herbicidal phenoxypyridines | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-08-30 | — | — | US | disclosed |
| EP-0021613-B1 | PYRIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM, HERBICIDAL COMPOSITIONS CONTAINING THEM AND METHODS OF KILLING PLANTS THEREWITH | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-04-06 | — | — | EP | disclosed |
| US-4308053-A | PREEMERGENCE AND POSTEMERGENCE | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-12-29 | — | — | US | disclosed |
| EP-0021613-A1 | Pyridine derivatives, processes for preparing them, herbicidal compositions containing them and methods of killing plants therewith | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | LIPE, PNLIP, LPL | MAPK1 3193/4885RAB9A 2926/4885THRB 348/4885 |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | LIPE, PNLIP, LPL | MAPK1 3078/4885RAB9A 3386/4885THRB 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.