Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3705956 | 0.96 | KMT2A (0.59) | KMT2ALMNAHTTTDP1NPSR1 | |
| SCHEMBL1651682 | 0.94 | LMNA (0.61) | KMT2ALMNAHTTTDP1NPSR1 | |
| Hydrochloric Acid SCHEMBL10806956 | 0.92 | LMNA (0.59) | KMT2ALMNAHTTTDP1NPSR1 | |
| SCHEMBL5802069 | 0.88 | HTT (0.69) | KMT2ALMNAHTTTDP1MEN1 | |
| SCHEMBL10272740 | 0.83 | TDP1 (0.62) | KMT2ALMNAHTTTDP1NPSR1 | |
| SCHEMBL4732560 | 0.83 | HTT (0.69) | KMT2ALMNAHTTTDP1MEN1 | |
| SCHEMBL19741751 | 0.82 | — | — | |
| SCHEMBL5572067 | 0.82 | KMT2A (0.54) | KMT2ALMNAHTTTDP1NPSR1 | |
| SCHEMBL5238995 | 0.82 | KMT2A (0.54) | KMT2ALMNAHTTTDP1NPSR1 | |
| SCHEMBL8397091 | 0.82 | HTT (0.62) | KMT2ALMNAHTTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059665-A1 | DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| CN-107438603-A | Pyrazole compounds and methods of making and using the same | 里格尔药品股份有限公司 | 2017-12-05 | — | — | CN | disclosed |