Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555741 | 0.87 | HTT (0.57) | KMT2AHTTMEN1TDP1CNR1 | |
| SCHEMBL5238596 | 0.84 | KMT2A (0.72) | KMT2AHTTMEN1TDP1POLB | |
| SCHEMBL24664428 | 0.82 | KMT2A (0.59) | KMT2ANPSR1HTTMEN1CYP2C19 | |
| SCHEMBL3705956 | 0.82 | KMT2A (0.59) | KMT2ANPSR1HTTMEN1CYP2C19 | |
| SCHEMBL4500837 | 0.80 | KMT2A (0.41) | KMT2AHTTCYP2C19TDP1MAPK1 | |
| SCHEMBL18170058 | 0.80 | KMT2A (0.49) | KMT2ANPSR1HTTMEN1CYP2C19 | |
| SCHEMBL1651682 | 0.80 | LMNA (0.61) | KMT2ANPSR1HTTMEN1CYP2C19 | |
| SCHEMBL10272740 | 0.78 | TDP1 (0.62) | KMT2ANPSR1HTTMEN1CYP2C19 | |
| Hydrochloric Acid SCHEMBL10806956 | 0.78 | LMNA (0.59) | KMT2ANPSR1HTTMEN1CYP2C19 | |
| SCHEMBL2760109 | 0.77 | HTT (0.77) | KMT2ANPSR1HTTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863809-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2006107753-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1863809-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107753-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |