Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.37 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30731795 | 1.00 | LTA4H (0.41) | LTA4HKCNH2PPARGLMNACYP2C9 | |
| SCHEMBL24664799 | 0.86 | LTA4H (0.51) | LTA4HKCNH2LMNACYP2C9TSHR | |
| SCHEMBL24665459 | 0.82 | LMNA (0.43) | LTA4HKCNH2PPARGLMNACYP2C9 | |
| SCHEMBL24665284 | 0.75 | EGFR (0.49) | LTA4HKCNH2PPARGLMNACYP2C9 | |
| SCHEMBL30731729 | 0.75 | EGFR (0.49) | LTA4HKCNH2PPARGLMNACYP2C9 | |
| SCHEMBL29123547 | 0.74 | LMNA (0.50) | LTA4HKCNH2LMNACYP2C9TSHR | |
| SCHEMBL27753623 | 0.72 | PIK3CD (0.44) | LTA4HLMNACYP2C9TSHRSMN1; SMN2 | |
| SCHEMBL24665287 | 0.72 | LTA4H (0.57) | LTA4HKCNH2PPARGCYP2C9 | |
| SCHEMBL13710426 | 0.71 | IDO1 (0.38) | LMNABACE1MAPK1 | |
| SCHEMBL746593 | 0.70 | IDO1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117015537-A | Heteroaryl aminopropanol derivatives as inhibitors of LTA4H | 诺华股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |