Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 16/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30005335 | 1.00 | LTA4H (0.49) | LTA4HSCN9AAAK1POLBMAPT | |
| SCHEMBL29123439 | 0.91 | LTA4H (0.53) | LTA4HSCN9A | |
| SCHEMBL24665364 | 0.87 | FFAR1 (0.39) | SCN9AMAPTTACR1 | |
| SCHEMBL24665387 | 0.87 | TACR1 (0.38) | SCN9APOLBMAPTMAPK1TACR1 | |
| SCHEMBL30006042 | 0.87 | LTA4H (0.56) | LTA4H | |
| SCHEMBL29123681 | 0.87 | LTA4H (0.56) | LTA4H | |
| SCHEMBL24665399 | 0.87 | LTA4H (0.56) | LTA4H | |
| SCHEMBL24664168 | 0.86 | SCN9A (0.43) | SCN9AMAPTMAPK1TACR1 | |
| SCHEMBL24665374 | 0.85 | PTPN1 (0.39) | SCN9APOLBMAPTMAPK1TACR1 | |
| SCHEMBL24664143 | 0.81 | PPARD (0.43) | LTA4HSCN9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |