Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF20A | O95235 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30007080 | 1.00 | KIF20A (0.49) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL24666267 | 0.91 | KIF20A (0.51) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL30006477 | 0.91 | KIF20A (0.51) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL2151881 | 0.90 | KIF20A (0.57) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL30006264 | 0.90 | KIF20A (0.57) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL2151892 | 0.90 | KIF20A (0.57) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL30968781 | 0.87 | KIF20A (0.49) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL2152283 | 0.87 | KIF20A (0.49) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL2152277 | 0.87 | KIF20A (0.49) | KIF20AMAPTKDM4EHTTTDP1 | |
| SCHEMBL2151672 | 0.85 | KIF20A (0.47) | KIF20AMAPTKDM4EHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117120416-A | Small molecule compound with substituted phenyl spiro [ indoline-3, 3' -pyrrolidine ] structure | 中国科学院上海药物研究所 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022218379-A1 | SMALL-MOLECULE COMPOUND HAVING SUBSTITUTED PHENYL SPIRO[INDOLINE-3,3'-PYRROLIDINE] STRUCTURE | 中国科学院上海药物研究所 | 2022-10-20 | — | — | WO | disclosed |