Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF20A | O95235 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2151892 | 1.00 | KIF20A (0.57) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL2151881 | 1.00 | KIF20A (0.57) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL30968781 | 0.92 | KIF20A (0.49) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL2152283 | 0.92 | KIF20A (0.49) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL2152277 | 0.92 | KIF20A (0.49) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL30492704 | 0.90 | KIF20A (0.59) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL30006379 | 0.90 | KIF20A (0.59) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL29018367 | 0.90 | KIF20A (0.59) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL24666239 | 0.90 | KIF20A (0.49) | KIF20AALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL30007080 | 0.90 | KIF20A (0.49) | KIF20AALDH1A1KDM4EPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118047784-A | Small molecule compound with substituted phenyl spiro [ indoline-3, 3' -pyrrolidine ] structure | 中国科学院上海药物研究所 | 2024-05-17 | — | — | CN | disclosed |
| CN-117120416-A | Small molecule compound with substituted phenyl spiro [ indoline-3, 3' -pyrrolidine ] structure | 中国科学院上海药物研究所 | 2023-11-24 | — | — | CN | disclosed |
| CN-115215872-A | Small molecule compound with substituted phenyl spiro [ indoline-3, 3' -pyrrolidine ] structure | 中国科学院上海药物研究所 | 2022-10-21 | — | — | CN | disclosed |