Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987068 | 1.00 | GRM5 (0.42) | GRM5MAP3K5PDE10AMCHR1SLC6A3 | |
| SCHEMBL24667346 | 0.92 | GRM5 (0.42) | GRM5PDE10AMCHR1SLC6A3NPC1 | |
| SCHEMBL29987375 | 0.92 | GRM5 (0.42) | GRM5PDE10AMCHR1SLC6A3NPC1 | |
| SCHEMBL24667596 | 0.90 | MAP3K5 (0.37) | GRM5MAP3K5MCHR1ADAM17 | |
| SCHEMBL24667655 | 0.89 | GRM5 (0.36) | GRM5MAP3K5PDE10AMCHR1NPC1 | |
| SCHEMBL29986550 | 0.86 | GRM5 (0.42) | GRM5PDE10AMCHR1SLC6A3 | |
| SCHEMBL24667400 | 0.86 | GRM5 (0.42) | GRM5PDE10AMCHR1SLC6A3 | |
| SCHEMBL24667405 | 0.86 | GRM5 (0.38) | GRM5PDE10ASLC6A3 | |
| SCHEMBL24667654 | 0.86 | GRM5 (0.38) | GRM5PDE10ASLC6A3 | |
| SCHEMBL29987630 | 0.86 | GRM5 (0.38) | GRM5PDE10ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220339302-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2022-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220339302-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | GRM5 1943/4885MAP3K5 2774/4885PDE10A 3530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.