Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987872 | 1.00 | NR1H4 (0.37) | NR1H4HTR2CGRM5PIK3CGCSNK1A1 | |
| SCHEMBL24667650 | 0.90 | PIK3CG (0.39) | NR1H4HTR2CGRM5PIK3CGCSNK1A1 | |
| SCHEMBL29987525 | 0.90 | PIK3CG (0.39) | NR1H4HTR2CGRM5PIK3CGCSNK1A1 | |
| SCHEMBL29986702 | 0.89 | NR1H4 (0.37) | NR1H4GRM5PIK3CGPRMT5WDR77 | |
| SCHEMBL24667426 | 0.89 | NR1H4 (0.37) | NR1H4GRM5PIK3CGPRMT5WDR77 | |
| SCHEMBL24667346 | 0.88 | GRM5 (0.42) | GRM5PIK3CGPRMT5WDR77 | |
| SCHEMBL29987375 | 0.88 | GRM5 (0.42) | GRM5PIK3CGPRMT5WDR77 | |
| SCHEMBL24667432 | 0.88 | PIK3CG (0.37) | NR1H4HTR2CGRM5PIK3CGCSNK1A1 | |
| SCHEMBL29987232 | 0.88 | PIK3CG (0.37) | NR1H4HTR2CGRM5PIK3CGCSNK1A1 | |
| SCHEMBL24667653 | 0.84 | PRMT5 (0.37) | NR1H4GRM5AOC3PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220339302-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2022-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220339302-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | NR1H4 4381/4885HTR2C 1010/4885GRM5 1943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.