Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24668629 | 0.85 | HTT (0.44) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL13510249 | 0.81 | STK17B (0.47) | KMT2AALDH1A1KDM4ESTK17BSTK17A | |
| SCHEMBL2944224 | 0.78 | KMT2A (0.38) | SYKKMT2AALDH1A1CA1CA2 | |
| SCHEMBL2944223 | 0.78 | KMT2A (0.38) | SYKKMT2AALDH1A1CA1CA2 | |
| SCHEMBL2944222 | 0.78 | KMT2A (0.38) | SYKKMT2AALDH1A1CA1CA2 | |
| SCHEMBL28734760 | 0.78 | ALDH1A1 (0.36) | SYKKMT2AALDH1A1CA1CA2 | |
| SCHEMBL29507814 | 0.78 | ALDH1A1 (0.36) | SYKKMT2AALDH1A1CA1CA2 | |
| SCHEMBL24541513 | 0.77 | STK17B (0.43) | ALDH1A1CA1CA2STK17BSTK17A | |
| SCHEMBL29678533 | 0.77 | STK17B (0.43) | ALDH1A1CA1CA2STK17BSTK17A | |
| SCHEMBL24668643 | 0.75 | STK17B (0.35) | CCNA2CDK2SYKALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |