Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LATS1 | O95835 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | FOS | P01100 | 1/20 | 0.30 |
| ▸ | JUN | P05412 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13510249 | 0.81 | STK17B (0.47) | STK17BSTK17AALDH1A1LATS1HTT | |
| SCHEMBL29678533 | 0.77 | STK17B (0.43) | STK17BSTK17AALDH1A1LATS1HTT | |
| SCHEMBL24541513 | 0.77 | STK17B (0.43) | STK17BSTK17AALDH1A1LATS1HTT | |
| SCHEMBL24668647 | 0.75 | CCNE2 (0.38) | STK17BSTK17AALDH1A1SYKMAPT | |
| SCHEMBL23141901 | 0.74 | ALDH1A1 (0.37) | ALDH1A1HTTSYKMAPTSMN1; SMN2 | |
| SCHEMBL23142051 | 0.74 | NUDT1 (0.40) | ALDH1A1HTTSYKMAPTSMN1; SMN2 | |
| SCHEMBL24669084 | 0.73 | ALDH1A1 (0.42) | ALDH1A1SYKMAPTLMNA | |
| SCHEMBL24668635 | 0.72 | CDK4 (0.35) | HTTCCNA2CDK2 | |
| SCHEMBL28492037 | 0.68 | TLR8 (0.49) | LMNACCNA2CDK2 | |
| SCHEMBL29497515 | 0.67 | SYK (0.55) | HTTSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |