SCHEMBL24670036

SCHEMBL24670036

Cc1cc(Br)c(F)cc1NC(=O)c1ccc(F)c(F)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.58
RAB9A P51151 3/20 0.58
KCNQ3 O43525 4/20 0.52
KCNQ2 O43526 4/20 0.52
HDAC1 Q13547 4/20 0.49
HDAC6 Q9UBN7 4/20 0.49
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
HDAC8 Q9BY41 2/20 0.46
POLB P06746 1/20 0.46
KCNK2 O95069 1/20 0.45
KCNK10 P57789 1/20 0.45
GAA P10253 1/20 0.45
DHODH Q02127 1/20 0.45
KCNQ5 Q9NR82 1/20 0.45
CYP11B1 P15538 1/20 0.44
CYP11B2 P19099 1/20 0.44
KCNE1 P15382 1/20 0.43
KCNQ1 P51787 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24669293 0.93 RAB9A (0.56) NPC1RAB9AKCNQ3KCNQ2HDAC1
SCHEMBL29803532 0.87 RAB9A (0.59) NPC1RAB9AHDAC1HDAC6KMT2A
SCHEMBL24669629 0.87 RAB9A (0.59) NPC1RAB9AHDAC1HDAC6KMT2A
SCHEMBL24670207 0.82 GPR27 (0.52) NPC1RAB9AHDAC1HDAC6KMT2A
SCHEMBL29803314 0.82 GPR27 (0.52) NPC1RAB9AHDAC1HDAC6KMT2A
SCHEMBL29803759 0.81 RAB9A (0.50) NPC1RAB9AKCNQ3KCNQ2HDAC1
SCHEMBL24670340 0.81 RAB9A (0.50) NPC1RAB9AKCNQ3KCNQ2HDAC1
SCHEMBL29803240 0.80 CYP1A2 (0.52) NPC1RAB9AHDAC1HDAC6KMT2A
SCHEMBL24669445 0.80 CYP1A2 (0.52) NPC1RAB9AHDAC1HDAC6KMT2A
SCHEMBL24670817 0.79 RAB9A (0.73) NPC1RAB9AHDAC1HDAC6KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed