Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794120 | 0.90 | NFKB1 (0.69) | PLK1ALDH1A1KDM4ENFKB1MEN1 | |
| SCHEMBL12561176 | 0.86 | PLK1 (0.55) | PLK1ALDH1A1KDM4ENFKB1MEN1 | |
| SCHEMBL659153 | 0.84 | P4HTM (0.69) | ALDH1A1KDM4ENFKB1MEN1LMNA | |
| SCHEMBL26970993 | 0.83 | PARP1 (0.51) | PLK1ALDH1A1KDM4ENFKB1MEN1 | |
| SCHEMBL30027907 | 0.83 | PARP1 (0.51) | PLK1ALDH1A1KDM4ENFKB1MEN1 | |
| SCHEMBL16597438 | 0.83 | PARP1 (0.51) | PLK1ALDH1A1KDM4ENFKB1MEN1 | |
| SCHEMBL2642502 | 0.81 | PARP1 (0.50) | PLK1ALDH1A1KDM4ENFKB1MEN1 | |
| SCHEMBL2642500 | 0.81 | PARP1 (0.50) | PLK1ALDH1A1KDM4ENFKB1MEN1 | |
| SCHEMBL26970992 | 0.81 | PARP1 (0.50) | PLK1ALDH1A1KDM4ENFKB1MEN1 | |
| SCHEMBL8150967 | 0.81 | ALDH1A1 (0.60) | PLK1ALDH1A1KDM4ENFKB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |