Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670231 | 0.86 | RAPGEF4 (0.60) | HTR6RAPGEF4HDAC3HDAC4HDAC1 | |
| SCHEMBL19791912 | 0.82 | RAPGEF4 (0.56) | HTR6RAPGEF4HDAC3HDAC4HDAC1 | |
| SCHEMBL30461633 | 0.78 | RAPGEF4 (0.71) | HTR6RAPGEF4HDAC3HDAC4HDAC1 | |
| SCHEMBL15598508 | 0.78 | RAPGEF4 (0.71) | HTR6RAPGEF4HDAC3HDAC4HDAC1 | |
| SCHEMBL4271635 | 0.77 | HTR6 (0.66) | HTR6RAPGEF4HDAC3HDAC4HDAC1 | |
| SCHEMBL15175316 | 0.76 | RAPGEF4 (1.00) | HTR6RAPGEF4HDAC3HDAC4HDAC1 | |
| SCHEMBL3828559 | 0.75 | RAPGEF4 (0.46) | HTR6RAPGEF4CYP19A1MAPTCDC7 | |
| SCHEMBL29558089 | 0.73 | HTR6 (0.61) | HTR6RAPGEF4MAPT | |
| SCHEMBL4065276 | 0.73 | HTR6 (0.61) | HTR6RAPGEF4MAPT | |
| SCHEMBL6643269 | 0.71 | RAPGEF4 (0.52) | HTR6RAPGEF4HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |