Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 2/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30811855 | 0.81 | EGFR (0.38) | KDM4EHDAC4SLC22A12POLBHCAR2 | |
| SCHEMBL1419363 | 0.81 | KDM4E (0.41) | KDM4ESLC22A12POLBHCAR2ROCK2 | |
| SCHEMBL1419851 | 0.78 | CHRNB2 (0.43) | KDM4ESLC22A12POLBHCAR2HTT | |
| SCHEMBL15365377 | 0.77 | KDR (0.43) | HTTSMN1; SMN2 | |
| SCHEMBL23912766 | 0.77 | KDM4E (0.34) | KDM4EHDAC4SLC22A12HTTPKM | |
| SCHEMBL31313551 | 0.77 | HTR7 (0.38) | KDM4EHTTPKMALDH1A1NPC1 | |
| SCHEMBL748039 | 0.76 | KDM4E (0.43) | KDM4EPOLBHCAR2ROCK2ROCK1 | |
| SCHEMBL23601345 | 0.76 | KDM4E (0.36) | KDM4EHDAC4SLC22A12POLBHCAR2 | |
| SCHEMBL23576878 | 0.76 | SLC22A12 (0.41) | KDM4EHDAC4SLC22A12POLBHCAR2 | |
| SCHEMBL22354069 | 0.74 | HDAC4 (0.49) | KDM4EHDAC4POLBHCAR2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |