Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 15/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066350 | 1.00 | PDE10A (0.48) | PDE10AOPRK1ACACB | |
| SCHEMBL31583655 | 0.84 | OPRK1 (0.44) | OPRK1ACACB | |
| SCHEMBL25141835 | 0.80 | ABL1 (0.39) | PDE10A | |
| SCHEMBL22907440 | 0.79 | OPRK1 (0.45) | OPRK1ACACB | |
| SCHEMBL22907129 | 0.78 | OPRK1 (0.38) | OPRK1ACACB | |
| SCHEMBL20354132 | 0.78 | OPRK1 (0.40) | OPRK1ACACB | |
| SCHEMBL29414945 | 0.78 | OPRK1 (0.40) | OPRK1ACACB | |
| SCHEMBL17316555 | 0.78 | HTT (0.41) | OPRK1ACACB | |
| SCHEMBL24881373 | 0.77 | OPRK1 (0.44) | OPRK1ACACB | |
| SCHEMBL25031006 | 0.77 | TYMP (0.39) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |