SCHEMBL24671109

SCHEMBL24671109

Cc1cc(C2=CCNCC2)c(F)cc1NC(=O)c1ccc(C2=CCNCC2)cc1F

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 2/20 0.49
CDK9 P50750 2/20 0.49
BRPF1 P55201 1/20 0.44
WDR5 P61964 2/20 0.44
QDPR P09417 3/20 0.40
HTR2C P28335 5/20 0.40
CSF1R P07333 1/20 0.38
NAMPT P43490 1/20 0.37
FTO Q9C0B1 1/20 0.37
CD274 Q9NZQ7 1/20 0.36
CHEK1 O14757 1/20 0.36
MAPKAPK2 P49137 1/20 0.36
BTK Q06187 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29803612 1.00 CCNT1 (0.49) CCNT1CDK9BRPF1WDR5QDPR
Trifluoroacetic Acid SCHEMBL29803381 0.94 CCNT1 (0.45) CCNT1CDK9BRPF1WDR5QDPR
SCHEMBL29803772 0.89 BTK (0.45) CCNT1CDK9BRPF1WDR5QDPR
SCHEMBL24669407 0.87 WDR5 (0.47) CCNT1CDK9BRPF1WDR5HTR2C
SCHEMBL29803489 0.87 WDR5 (0.47) CCNT1CDK9BRPF1WDR5HTR2C
SCHEMBL29803677 0.85 CCNT1 (0.50) CCNT1CDK9BRPF1QDPRHTR2C
SCHEMBL24670608 0.85 CCNT1 (0.50) CCNT1CDK9BRPF1QDPRHTR2C
SCHEMBL24670985 0.84 WNT3A (0.44) CCNT1CDK9BRPF1WDR5HTR2C
SCHEMBL29803250 0.84 WNT3A (0.44) CCNT1CDK9BRPF1WDR5HTR2C
SCHEMBL24669469 0.82 CCNT1 (0.48) CCNT1CDK9WDR5QDPRHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed