Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10727400 | 0.85 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL25139669 | 0.82 | L3MBTL1 (0.55) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL15061717 | 0.81 | KMT2A (0.50) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL2619354 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL19110994 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1TP53KDM4E | |
| SCHEMBL16252551 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL22540339 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL9764596 | 0.77 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL24670521 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL19699499 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1RAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |