Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30801207 | 1.00 | SUV39H2 (0.48) | SUV39H2PDE7AMAPTMEN1LMNA | |
| SCHEMBL1912064 | 0.84 | SUV39H2 (0.47) | SUV39H2PDE7AMAPTLMNAMAPK1 | |
| SCHEMBL1911948 | 0.83 | SUV39H2 (0.46) | SUV39H2PDE7AMAPTACHEALDH1A1 | |
| SCHEMBL18640030 | 0.82 | SUV39H2 (0.49) | SUV39H2PDE7AMAPTACHEALDH1A1 | |
| SCHEMBL24670695 | 0.81 | ADRB1 (0.41) | SUV39H2MAPTMEN1LMNAKMT2A | |
| SCHEMBL30066216 | 0.81 | ADRB1 (0.41) | SUV39H2MAPTMEN1LMNAKMT2A | |
| SCHEMBL1912084 | 0.80 | SUV39H2 (0.44) | SUV39H2PDE7AMAPTLMNAACHE | |
| SCHEMBL30768476 | 0.79 | MAPT (0.42) | SUV39H2MAPTMEN1LMNAKMT2A | |
| SCHEMBL16431871 | 0.79 | SUV39H2 (0.47) | SUV39H2MAPTMEN1LMNAKMT2A | |
| SCHEMBL23705839 | 0.79 | ALDH1A1 (0.55) | SUV39H2MAPTMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |