Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066309 | 1.00 | PDE10A (0.40) | PDE10ALRRK2CYP11B2HRH4MAPK8 | |
| SCHEMBL23459570 | 0.89 | PRMT5 (0.41) | PDE10ALRRK2 | |
| SCHEMBL29872807 | 0.89 | PRMT5 (0.41) | PDE10ALRRK2 | |
| SCHEMBL23983537 | 0.88 | LRRK2 (0.44) | LRRK2CYP11B2HRH4ALDH1A1SMN1; SMN2 | |
| SCHEMBL30801285 | 0.86 | ALDH1A1 (0.49) | CYP11B2HRH4ALDH1A1SMN1; SMN2 | |
| SCHEMBL29207709 | 0.86 | HRH4 (0.42) | PDE10ACYP11B2HRH4ALDH1A1SMN1; SMN2 | |
| SCHEMBL25031024 | 0.85 | FFAR4 (0.46) | — | |
| SCHEMBL24670691 | 0.85 | ALOX5AP (0.39) | PDE10ALRRK2 | |
| SCHEMBL30066345 | 0.85 | ALOX5AP (0.39) | PDE10ALRRK2 | |
| SCHEMBL25074514 | 0.84 | LRRK2 (0.42) | PDE10ALRRK2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |