SCHEMBL24671462

SCHEMBL24671462

Cc1cc(C2=CCNCC2)ccc1NC(=O)c1ccc(C2=CCN(C)CC2)cc1C

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 1/20 0.42
QDPR P09417 6/20 0.42
BRPF1 P55201 1/20 0.41
NAMPT P43490 1/20 0.38
WDR5 P61964 1/20 0.37
CCR8 P51685 1/20 0.36
FTO Q9C0B1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29803546 0.90 QDPR (0.47) CSF1RQDPRBRPF1NAMPTFTO
SCHEMBL24671471 0.88 CSF1R (0.40) CSF1RQDPRBRPF1NAMPT
Trifluoroacetic Acid SCHEMBL29803385 0.83 QDPR (0.41) CSF1RQDPRBRPF1NAMPTWDR5
SCHEMBL24670766 0.82 QDPR (0.41) QDPRNAMPTCCR8
SCHEMBL29803540 0.79 HTR2C (0.43) CSF1RQDPRBRPF1NAMPTWDR5
SCHEMBL29803534 0.78 BRPF1 (0.44) CSF1RQDPRBRPF1NAMPTWDR5
SCHEMBL24670128 0.77 CCNT1 (0.50) QDPRNAMPTFTO
SCHEMBL29803542 0.77 BRPF1 (0.41) CSF1RQDPRBRPF1NAMPTWDR5
SCHEMBL24670760 0.77 NAMPT (0.45) QDPRNAMPT
SCHEMBL29803364 0.76 QDPR (0.42) CSF1RQDPRBRPF1NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed