Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10191387 | 0.91 | ACHE (0.50) | ACHECHRM5ADRA2CSIGMAR1 | |
| SCHEMBL26480974 | 0.91 | ACHE (0.50) | ACHECHRM5ADRA2CSMN1; SMN2HRH3 | |
| SCHEMBL22520700 | 0.91 | ACHE (0.50) | ACHECHRM5ADRA2CSMN1; SMN2HRH3 | |
| SCHEMBL178287 | 0.91 | SMN1; SMN2 (0.46) | ACHESMN1; SMN2HRH3EPHX1 | |
| SCHEMBL24838817 | 0.89 | KMT2A (0.42) | ACHECHRM5ADRA2CSMN1; SMN2HRH3 | |
| SCHEMBL26809208 | 0.87 | ACHE (0.39) | ACHECHRM5ADRA2CSMN1; SMN2HRH3 | |
| SCHEMBL12605240 | 0.86 | CHRM5 (0.60) | ACHECHRM5ADRA2CSMN1; SMN2HRH3 | |
| SCHEMBL22874766 | 0.86 | ACHE (0.63) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 | |
| SCHEMBL11919255 | 0.86 | CHRM5 (0.54) | ACHECHRM5ADRA2CSMN1; SMN2HRH3 | |
| SCHEMBL20127903 | 0.86 | ACHE (0.57) | ACHECHRM5ADRA2CSMN1; SMN2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023240038-A1 | TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |