Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22520700 | 1.00 | ACHE (0.50) | ACHECHRM5ADRA2CSMN1; SMN2KDM4E | |
| SCHEMBL3477990 | 0.92 | CHRM5 (0.48) | ACHECHRM5ADRA2CSMN1; SMN2KDM4E | |
| SCHEMBL24334496 | 0.91 | NCF1 (0.45) | ACHECHRM5ADRA2CSMN1; SMN2KDM4E | |
| SCHEMBL27289735 | 0.91 | ACHE (0.44) | ACHECHRM5ADRA2CSMN1; SMN2KDM4E | |
| SCHEMBL20331226 | 0.91 | ACHE (0.44) | ACHECHRM5ADRA2CSMN1; SMN2KDM4E | |
| SCHEMBL12605240 | 0.91 | CHRM5 (0.60) | ACHECHRM5ADRA2CSMN1; SMN2HRH3 | |
| SCHEMBL24671546 | 0.91 | ACHE (0.47) | ACHECHRM5ADRA2CSMN1; SMN2HRH3 | |
| SCHEMBL11919255 | 0.91 | CHRM5 (0.54) | ACHECHRM5ADRA2CSMN1; SMN2KDM4E | |
| SCHEMBL23173752 | 0.89 | ACHE (0.42) | ACHECHRM5ADRA2CSMN1; SMN2KDM4E | |
| SCHEMBL27269612 | 0.89 | ACHE (0.42) | ACHECHRM5ADRA2CSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |