SCHEMBL24671548

SCHEMBL24671548

CC(C)(C)OC(=O)/N=C(/NCc1ccc(NC(=O)c2ccc(C3=CCN(/C(=N\C(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)CC3)s2)cc1)NC(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 8/20 0.39
TP53 P04637 1/20 0.37
KIT P10721 2/20 0.36
MAPT P10636 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
ACKR3 P25106 1/20 0.34
HDAC1 Q13547 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
WNT3A P56704 1/20 0.33
ROCK2 O75116 1/20 0.33
XBP1 P17861 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
GPR55 Q9Y2T6 1/20 0.33
DRD2 P14416 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29803457 0.91 NAMPT (0.47) NAMPTRXFP1KDM4ELMNASMN1; SMN2
SCHEMBL29803846 0.88 MAPT (0.37) NAMPTTP53KITMAPTACKR3
SCHEMBL29803497 0.88 NAMPT (0.37) NAMPTTP53MAPTACKR3HDAC1
SCHEMBL24671335 0.88 MAPT (0.37) NAMPTTP53KITMAPTACKR3
SCHEMBL24669232 0.88 NAMPT (0.39) NAMPTKITMAPTTDP1HDAC1
SCHEMBL29803669 0.88 NAMPT (0.39) NAMPTKITMAPTTDP1HDAC1
SCHEMBL24669388 0.88 NAMPT (0.44) NAMPTMAPTTDP1HDAC1HDAC6
SCHEMBL30182331 0.88 NAMPT (0.44) NAMPTMAPTTDP1HDAC1HDAC6
SCHEMBL24669386 0.88 NAMPT (0.44) NAMPTMAPTTDP1HDAC1HDAC6
SCHEMBL24670464 0.88 HDAC3 (0.40) NAMPTKITMAPTTDP1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed