SCHEMBL24671549

SCHEMBL24671549

N=C(N)NCc1ccc(NC(=O)c2ccc(C3=CCN(C(=N)N)CC3)s2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.40
RXFP1 Q9HBX9 1/20 0.37
ESRRG P62508 4/20 0.36
MAPT P10636 1/20 0.36
TMPRSS2 O15393 3/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
F2 P00734 1/20 0.36
PPARG P37231 1/20 0.36
NCOA2 Q15596 1/20 0.36
NCOA1 Q15788 1/20 0.36
NCOA3 Q9Y6Q9 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
ALDH1A1 P00352 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
MAPKAPK2 P49137 1/20 0.35
HDAC3 O15379 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24671416 0.89 TP53 (0.37) TP53RXFP1ESRRGTMPRSS2NPC1
SCHEMBL29803084 0.87 ESRRG (0.46) RXFP1ESRRGMAPTNPC1RAB9A
SCHEMBL29802997 0.85 PTPN11 (0.39) TP53MAPTTMPRSS2F2ROCK2
SCHEMBL24669239 0.85 MMP12 (0.38) TP53MAPTTMPRSS2NPC1RAB9A
SCHEMBL24671339 0.84 MAPT (0.41) RXFP1ESRRGMAPTTMPRSS2NPC1
SCHEMBL29803264 0.84 RXFP1 (0.34) TP53RXFP1ESRRGMAPTTMPRSS2
SCHEMBL24891885 0.84 TMPRSS2 (0.45) MAPTTMPRSS2NPC1RAB9AF2
SCHEMBL24669387 0.84 TMPRSS2 (0.45) MAPTTMPRSS2NPC1RAB9AF2
Trifluoroacetic Acid SCHEMBL29803711 0.84 TP53 (0.36) TP53RXFP1NPC1RAB9ASMN1; SMN2
SCHEMBL24671486 0.82 MAPT (0.38) TP53MAPTTMPRSS2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO claimed
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed