SCHEMBL24671588

SCHEMBL24671588

COC(=O)c1ccc(N2CCN(C)CC2)s1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.45
NPSR1 Q6W5P4 2/20 0.45
PPARG P37231 1/20 0.45
NCOA2 Q15596 1/20 0.45
NCOA1 Q15788 1/20 0.45
NCOA3 Q9Y6Q9 1/20 0.45
GPX4 P36969 2/20 0.43
FGFR1 P11362 1/20 0.42
SIRT6 Q8N6T7 1/20 0.42
KMT2A Q03164 3/20 0.41
MAPK1 P28482 3/20 0.41
HPGD P15428 5/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
TSHR P16473 1/20 0.41
ATM Q13315 1/20 0.41
KDM4E B2RXH2 5/20 0.40
ALDH1A1 P00352 3/20 0.40
MEN1 O00255 1/20 0.40
USP2 O75604 1/20 0.40
PKM P14618 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4438126 0.85 DAO (0.44) LMNAGPX4FGFR1KMT2AMAPK1
SCHEMBL64523 0.85 LMNA (0.43) LMNANPSR1PPARGNCOA2NCOA1
SCHEMBL64634 0.84 HDAC3 (0.48) LMNAKMT2AMAPK1HPGDL3MBTL1
SCHEMBL4554523 0.80 CHKA (0.41) LMNAKMT2AMAPK1KDM4EALDH1A1
Hydrochloric Acid SCHEMBL3282609 0.80 NPSR1 (0.41) LMNANPSR1PPARGNCOA2NCOA1
SCHEMBL63716 0.79 HDAC3 (0.44) NPSR1KMT2AMAPK1HPGDL3MBTL1
SCHEMBL27787976 0.79 HPGD (0.41) LMNANPSR1PPARGNCOA2NCOA1
SCHEMBL63589 0.79 NR1H2 (0.48) LMNANPSR1KMT2AMAPK1HPGD
SCHEMBL28987789 0.79 NPSR1 (0.40) LMNANPSR1PPARGNCOA2NCOA1
SCHEMBL277132 0.76 KMT2A (0.68) LMNANPSR1PPARGNCOA2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed