Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LIG1 | P18858 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438126 | 0.94 | DAO (0.44) | DAOLMNAKMT2AMAPK1NPC1 | |
| SCHEMBL5226095 | 0.85 | ALDH1A1 (0.46) | DAOKMT2ARAB9APKMLIG1 | |
| SCHEMBL5228374 | 0.84 | KMT2A (0.49) | DAOKMT2ANPC1RAB9APKM | |
| SCHEMBL63716 | 0.81 | HDAC3 (0.44) | CHKAKMT2AMAPK1RAB9AKDM4E | |
| SCHEMBL24671588 | 0.80 | LMNA (0.45) | CHKALMNAKMT2AMAPK1NPC1 | |
| SCHEMBL4441335 | 0.77 | CHRNA7 (0.45) | DAOLMNAKMT2ANPC1RAB9A | |
| SCHEMBL82260 | 0.76 | CHKA (0.42) | CHKALMNAKMT2APKMNCF1 | |
| SCHEMBL7826262 | 0.74 | ALDH1A1 (0.49) | LMNAKMT2ASMN1; SMN2POLBKDM4E | |
| SCHEMBL64634 | 0.74 | HDAC3 (0.48) | LMNAKMT2AMAPK1KDM4EALDH1A1 | |
| SCHEMBL6274318 | 0.73 | DAO (0.39) | DAOKMT2ARAB9APKMLIG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |