Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 8/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 8/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24673113 | 0.96 | CYP11B2 (0.42) | ROCK1CDC42BPBTSHRHSD17B10CYP11B2 | |
| SCHEMBL24673049 | 0.95 | EIF2AK4 (0.42) | ROCK1CDC42BPBROCK2CDC42BPAEIF2AK4 | |
| SCHEMBL24673069 | 0.75 | ROCK1 (0.45) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL20757850 | 0.74 | CDC42BPB (0.63) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL24672167 | 0.74 | CDC42BPB (0.63) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL24672492 | 0.74 | CDC42BPB (0.63) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL24672917 | 0.73 | ROCK1 (0.41) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL24672118 | 0.73 | ROCK1 (0.56) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL24672409 | 0.73 | ROCK1 (0.62) | ROCK1CDC42BPBCYP11B2ROCK2CDC42BPA | |
| SCHEMBL13156801 | 0.72 | CYP11B2 (0.52) | TSHRHSD17B10CYP11B2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | PDXK, CCNK, CDC42BPB | ROCK1 1054/4885CDC42BPB 3/4885TSHR 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.