Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 12/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 12/20 | 0.57 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30812588 | 1.00 | CHRNB4 (0.57) | CHRNB4CHRNA3NISCHCHRNA7MAPT | |
| SCHEMBL29833755 | 0.96 | CHRNB4 (0.52) | CHRNB4CHRNA3NISCHCHRNA7MAPT | |
| SCHEMBL17353143 | 0.79 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNA7MAPTLMNA | |
| SCHEMBL20508918 | 0.78 | CHRNB4 (0.55) | CHRNB4CHRNA3CHRNA7MAPTTSHR | |
| SCHEMBL25282712 | 0.78 | CHRNB4 (0.55) | CHRNB4CHRNA3CHRNA7MAPTTSHR | |
| SCHEMBL9633955 | 0.76 | CHRNB4 (0.52) | CHRNB4CHRNA3NISCHCHRNA7MAPT | |
| SCHEMBL29420191 | 0.73 | CHRNB4 (0.49) | CHRNB4CHRNA3NISCHCHRNA7MAPT | |
| SCHEMBL1429750 | 0.73 | CHRNB4 (0.49) | CHRNB4CHRNA3NISCHCHRNA7MAPT | |
| SCHEMBL895500 | 0.72 | CHRNB4 (1.00) | CHRNB4CHRNA3NISCHCHRNA7MAPT | |
| SCHEMBL2323955 | 0.72 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNA7MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368204-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2024-11-07 | — | — | US | disclosed |
| EP-4353732-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2024-04-17 | — | — | EP | disclosed |
| CN-117642411-A | Small molecule CD73 antagonists and uses thereof | 西藏海思科制药有限公司 | 2024-03-01 | — | — | CN | disclosed |
| WO-2022237747-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | 四川海思科制药有限公司 | 2022-11-17 | — | — | WO | disclosed |
| WO-2022237747-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | 四川海思科制药有限公司 | 2022-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368204-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | ENTPD5, ENTPD1, ENTPD2 | CHRNB4 642/4885CHRNA3 306/4885NISCH 3488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.