SCHEMBL24672913

SCHEMBL24672913

C[C@H](O)CN1CCN(Cc2ccc(C(=O)O)cc2)CN(C[C@H](C)O)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.46
HDAC4 P56524 3/20 0.46
KCNH2 Q12809 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.45
GAA P10253 2/20 0.45
THRB P10828 2/20 0.45
LMNA P02545 1/20 0.45
HDAC6 Q9UBN7 2/20 0.45
ALDH1A1 P00352 2/20 0.44
KDM4E B2RXH2 2/20 0.44
MEN1 O00255 1/20 0.44
USP2 O75604 1/20 0.44
POLB P06746 1/20 0.44
MAPT P10636 1/20 0.44
NR4A1 P22736 1/20 0.44
APEX1 P27695 1/20 0.44
APOBEC3A P31941 1/20 0.44
RECQL P46063 1/20 0.44
KMT2A Q03164 1/20 0.44
HIF1A Q16665 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10903263 0.93 HDAC1 (0.52) HDAC1HDAC4KCNH2SMN1; SMN2GAA
SCHEMBL10900440 0.82 EBP (0.51) HDAC1HDAC4KCNH2MEN1KMT2A
SCHEMBL24673196 0.80 HDAC1 (0.47) HDAC1HDAC4KCNH2SMN1; SMN2GAA
SCHEMBL24672617 0.79 SIGMAR1 (0.55) KCNH2SMN1; SMN2LMNAPOLBCYP2D6
SCHEMBL10074441 0.78 HDAC1 (0.62) HDAC1HDAC4KCNH2SMN1; SMN2GAA
SCHEMBL10900938 0.78 CHKA (0.60) HDAC1HDAC4KCNH2SMN1; SMN2GAA
SCHEMBL24462523 0.77 HRH4 (0.54) HDAC1HDAC6MEN1KMT2AHRH3
SCHEMBL27486206 0.77 HRH3 (0.66) HDAC1HDAC4KCNH2SMN1; SMN2GAA
SCHEMBL22014467 0.76 HDAC1 (0.54) HDAC1HDAC4KCNH2HDAC6ALDH1A1
SCHEMBL21797152 0.76 KDM4E (0.68) SMN1; SMN2GAALMNAALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022204065-A1 IRON(III) MACROCYCLIC COMPLEXES WITH MIXED HYROXYL PENDANTS AS MRI CONTRAST AGENTS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2022-09-29 WO disclosed