Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.42 |
| ▸ | JAK1 | P23458 | 5/20 | 0.42 |
| ▸ | TYK2 | P29597 | 5/20 | 0.42 |
| ▸ | JAK3 | P52333 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL141168 | 0.86 | JAK2 (0.44) | JAK2JAK1BTK | |
| SCHEMBL146631 | 0.81 | JAK2 (0.44) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL15789661 | 0.77 | JAK2 (0.71) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL139088 | 0.76 | JAK2 (0.61) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL13284311 | 0.76 | JAK2 (0.59) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL4947674 | 0.74 | ALDH1A1 (0.50) | MEN1ALDH1A1MAPTALOX15KMT2A | |
| SCHEMBL141907 | 0.71 | JAK2 (0.56) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL143095 | 0.71 | MEN1 (0.49) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL28827483 | 0.71 | SMN1; SMN2 (0.40) | MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16262603 | 0.70 | QDPR (0.47) | MEN1USP2ALDH1A1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |