SCHEMBL24673219

SCHEMBL24673219

C[C@H](O)CN1CCN(Cc2ccncc2O)CCN(C[C@H](C)O)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MPO P05164 1/20 0.42
CACNA1B Q00975 1/20 0.40
DRD2 P14416 3/20 0.38
DRD3 P35462 3/20 0.38
MAOB P27338 1/20 0.37
BRD4 O60885 2/20 0.36
TP53 P04637 2/20 0.36
NFKB1 P19838 2/20 0.36
NFKB2 Q00653 2/20 0.36
RELA Q04206 2/20 0.36
USP2 O75604 1/20 0.36
ALOX15 P16050 1/20 0.36
DRD4 P21917 1/20 0.36
SLC6A3 Q01959 1/20 0.36
FABP6 P51161 1/20 0.36
KDM4E B2RXH2 2/20 0.36
GAA P10253 2/20 0.36
MAPT P10636 2/20 0.36
ALDH1A1 P00352 2/20 0.35
LMNA P02545 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24673205 0.87 MPO (0.33) MPOCACNA1BDRD2DRD3MAOB
SCHEMBL29943113 0.79 MPO (0.71) MPODRD2DRD3ALOX15KDM4E
SCHEMBL24672941 0.79 MPO (0.71) MPODRD2DRD3ALOX15KDM4E
SCHEMBL24672649 0.79 MPO (0.71) MPODRD2DRD3ALOX15KDM4E
SCHEMBL4732925 0.76 CYP2C9 (0.57) MPOCACNA1BALOX15KDM4EGAA
SCHEMBL24673202 0.76 MPO (0.39) MPOCACNA1BMAOBBRD4TP53
SCHEMBL24672650 0.74 MPO (0.53) MPODRD2DRD3MAOBALOX15
SCHEMBL24673245 0.70 MPO (0.56) MPODRD2DRD3ALOX15KDM4E
SCHEMBL29942613 0.69 GAA (0.57) KDM4EGAAMAPTALDH1A1LMNA
SCHEMBL8860654 0.68 DRD2 (0.47) DRD2DRD3BRD4USP2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4308177-A1 IRON(III) MACROCYCLIC COMPLEXES WITH MIXED HYROXYL PENDANTS AS MRI CONTRAST AGENTS The Research Foundation for The State University of New York (US) 2024-01-24 EP disclosed
WO-2022204065-A1 IRON(III) MACROCYCLIC COMPLEXES WITH MIXED HYROXYL PENDANTS AS MRI CONTRAST AGENTS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2022-09-29 WO disclosed
WO-2022204065-A1 IRON(III) MACROCYCLIC COMPLEXES WITH MIXED HYROXYL PENDANTS AS MRI CONTRAST AGENTS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2022-09-29 WO disclosed