Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 10/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26408734 | 0.92 | CYP2D6 (0.40) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B | |
| SCHEMBL25829191 | 0.91 | CYP2D6 (0.40) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B | |
| SCHEMBL23945421 | 0.89 | OPRL1 (0.39) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B | |
| SCHEMBL25707305 | 0.88 | CA2 (0.41) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B | |
| SCHEMBL25923662 | 0.87 | CYP2D6 (0.47) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B | |
| SCHEMBL23806767 | 0.86 | CYP2D6 (0.44) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B | |
| SCHEMBL25924028 | 0.86 | L3MBTL1 (0.42) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B | |
| SCHEMBL27107664 | 0.86 | CYP2D6 (0.56) | CYP2D6ALDH1A1CYP3A4MAPK1CYP2C9 | |
| SCHEMBL25702021 | 0.85 | CYP2D6 (0.42) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B | |
| SCHEMBL25654337 | 0.85 | CYP2D6 (0.52) | CYP2D6ALDH1A1CYP3A4ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340570-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340570-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | CYP2D6 3599/4885ALDH1A1 2776/4885CYP3A4 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.