Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 2/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 16/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 14/20 | 0.49 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.47 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22797506 | 0.80 | PRMT5 (0.65) | PRMT5WDR77 | |
| SCHEMBL22797513 | 0.80 | PRMT5 (0.65) | PRMT5WDR77 | |
| SCHEMBL22797568 | 0.80 | PRMT5 (0.65) | PRMT5WDR77 | |
| SCHEMBL22799499 | 0.80 | PRMT5 (0.65) | PRMT5WDR77 | |
| SCHEMBL22486869 | 0.79 | PRMT5 (0.47) | ADKPRMT5WDR77 | |
| SCHEMBL22486866 | 0.77 | PRMT5 (0.46) | ADKPRMT5WDR77METTL3 | |
| SCHEMBL31228198 | 0.77 | ADK (0.57) | ADKPRMT5WDR77METTL3 | |
| SCHEMBL31228134 | 0.75 | ADK (0.55) | ADKPRMT5WDR77METTL3 | |
| SCHEMBL20418972 | 0.74 | ADK (0.62) | ADKPRMT5WDR77RAPGEF3 | |
| SCHEMBL29485644 | 0.74 | ADK (0.59) | ADKPRMT5WDR77RAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | ADK 361/4885PRMT5 3663/4885WDR77 3289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.