Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2468002 | 0.94 | MET (0.65) | METTSHR | |
| SCHEMBL2470606 | 0.92 | MET (0.53) | METTSHRUSP2KDM4EMAPT | |
| SCHEMBL2466179 | 0.91 | MET (0.56) | METTSHRUSP2KDM4EMAPT | |
| SCHEMBL2471696 | 0.90 | MET (0.51) | METTSHRUSP2KDM4EMAPT | |
| SCHEMBL2466850 | 0.89 | MET (0.52) | METTSHRUSP2KDM4EMAPT | |
| SCHEMBL2471207 | 0.89 | MET (0.62) | METTSHR | |
| SCHEMBL2472319 | 0.87 | MET (0.51) | METTSHRUSP2KDM4EMAPT | |
| SCHEMBL2469403 | 0.87 | MET (0.51) | METTSHRUSP2KDM4ECNR2 | |
| SCHEMBL2468920 | 0.86 | MET (0.53) | METTSHR | |
| SCHEMBL2470250 | 0.86 | MET (0.63) | METTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173653-B2 | Pyridiazinone derivatives for the treatment of tumours | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2012-05-08 | — | — | US | claimed |
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | claimed |